Abstract
L1-transfected L cells show a markedly enhanced ability for neuronal cell binding and promotion of neuron migration compared with control L cells. Further, when purified L1 was used as a culture substrate for neurons, it was found to promote neuronal adhesion and enhance the speed of migration of cerebellar neurons from reaggregated cultures, indicating that it is involved in a determinant step of neural cell migration.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Animals, Newborn
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Cell Adhesion Molecules, Neuronal / genetics
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Cell Adhesion Molecules, Neuronal / physiology*
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Cell Movement / physiology*
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Cells, Cultured
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Cerebellum / physiology*
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Cloning, Molecular
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Fluorescent Antibody Technique
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Leukocyte L1 Antigen Complex
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Mice
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Neurons / physiology*
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Rats
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Transfection
Substances
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Cell Adhesion Molecules, Neuronal
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Leukocyte L1 Antigen Complex