Abstract
In CNS synapses, the synaptic junctional complex with associated postsynaptic density is presumed to contain proteins responsible for adhesion between pre- and postsynaptic membranes and for postsynaptic signal transduction. We have found that a prominent, brain-specific protein (PSD-95) enriched in the postsynaptic density fraction from rat brain is highly similar to the Drosophila lethal(1)discs-large-1 (dlg) tumor suppressor protein. The dlg protein is associated with septate junctions in developing flies and contains a guanylate kinase domain that is required for normal control of cell division. The sequence similarity between dlg and PSD-95 suggests that molecular mechanisms critical for growth control in developing organisms may also regulate synapse formation, stabilization, or function in the adult brain.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Brain / embryology
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Brain / growth & development
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Brain / physiology
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Brain Chemistry*
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DNA / chemistry
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Dendrites / chemistry
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Disks Large Homolog 4 Protein
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Drosophila Proteins*
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Gene Expression
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Insect Hormones / chemistry*
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Intracellular Signaling Peptides and Proteins
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Membrane Proteins
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Molecular Sequence Data
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Nerve Tissue Proteins / chemistry*
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Nerve Tissue Proteins / genetics
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RNA, Messenger / analysis
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Rats
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Sequence Homology, Amino Acid
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Synapses / chemistry*
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Synapses / physiology
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Tissue Distribution
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Tumor Suppressor Proteins*
Substances
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Disks Large Homolog 4 Protein
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Dlg4 protein, rat
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Drosophila Proteins
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Insect Hormones
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Intracellular Signaling Peptides and Proteins
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Membrane Proteins
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Nerve Tissue Proteins
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RNA, Messenger
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Tumor Suppressor Proteins
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postsynaptic density proteins
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dlg1 protein, Drosophila
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DNA