A continuing signal maintains NGF receptor expression in hypoglossal motor neurons after crush injury

D M Greeson; L Moix; M Meier; D M Armstrong; R G Wiley

doi:10.1016/0006-8993(92)91151-4

A continuing signal maintains NGF receptor expression in hypoglossal motor neurons after crush injury

Brain Res. 1992 Oct 30;594(2):351-5. doi: 10.1016/0006-8993(92)91151-4.

Authors

D M Greeson¹, L Moix, M Meier, D M Armstrong, R G Wiley

Affiliation

¹ Neurology Department, DVAMC, Nashville, TN 37212-2637.

PMID: 1450963
DOI: 10.1016/0006-8993(92)91151-4

Abstract

Inhibition of axonal transport by vincristine applied to hypoglossal nerves 7 days after crush injury turns off the usual injured-induced expression of low affinity nerve growth factor receptor (p75NGFr). Vincristine applied proximal but not distal to the crush prevents p75NGFr induction. These results indicate that a continuing signal is axonally transported from the crush site that induces and maintains p75NGFr expression by injured motor neurons.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Hypoglossal Nerve / cytology
Hypoglossal Nerve / drug effects
Hypoglossal Nerve / metabolism*
Male
Motor Neurons / drug effects
Motor Neurons / metabolism*
Nerve Crush*
Rats
Rats, Sprague-Dawley
Receptors, Nerve Growth Factor / drug effects
Receptors, Nerve Growth Factor / metabolism*
Signal Transduction / drug effects
Signal Transduction / physiology*
Vincristine / pharmacology

Substances

Receptors, Nerve Growth Factor
Vincristine