Abstract
Focal epilepsies of the mesial temporal lobe are often associated with a hippocampal sclerosis. Changes in Cl homeostasis and GABAergic signalling in downstream regions, may contribute to the human pathology. A review of changes in cellular and synaptic function and connectivity after de-afferentation suggests this epileptic syndrome may involve a pathological replay of developmental mechanisms.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Brain / embryology*
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Chlorides / metabolism
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Electroencephalography
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Epilepsy / pathology*
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Epilepsy, Temporal Lobe / embryology*
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Epilepsy, Temporal Lobe / pathology*
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Hippocampus / pathology
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Humans
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Sclerosis / pathology
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Signal Transduction
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Synapses / metabolism
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Temporal Lobe / pathology*
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gamma-Aminobutyric Acid / metabolism
Substances
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Chlorides
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gamma-Aminobutyric Acid