Modelling the controls of the eukaryotic cell cycle

B Novák; J J Tyson

doi:10.1042/bst0311526

Modelling the controls of the eukaryotic cell cycle

Biochem Soc Trans. 2003 Dec;31(Pt 6):1526-9. doi: 10.1042/bst0311526.

Authors

B Novák¹, J J Tyson

Affiliation

¹ Molecular Network Dynamics Research Group of Hungarian Academy of Sciences and Budapest University of Technology and Economics, 1521 Budapest, Gellért tér 4, Hungary. bnovak@mail.bme.hu

PMID: 14641104
DOI: 10.1042/bst0311526

Abstract

The eukaryotic cell-division cycle is regulated by three modules that control G(1)/S, G(2)/M and meta/anaphase transitions. By using mathematical modelling, we show the dynamic characteristics of these individual modules and we also assemble them together into a comprehensive model of the eukaryotic cell-division cycle. With this comprehensive model, we also discuss the mechanisms by which different checkpoint pathways stabilize different cell-cycle states and inhibit the transitions that drive cell-cycle progression.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Cell Cycle*
Eukaryotic Cells
Models, Biological*