Abstract
In a widely held view of vertebrate CNS development, neurons, astrocytes, and oligodendrocytes arise from a common tripotent progenitor cell. However, tripotent progenitors have never been detected in developing embryos. In this issue of Neuron, Gabay et al. show that tripotent progenitors can be created in vitro by deregulation of normal dorsoventral positional cues.
Publication types
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Comment
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Comparative Study
MeSH terms
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Animals
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Astrocytes / metabolism
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Body Patterning / physiology
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Cell Aggregation
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Cell Culture Techniques
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Cell Differentiation / physiology*
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Central Nervous System / cytology
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Central Nervous System / embryology
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Central Nervous System / physiology*
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Hedgehog Proteins
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Mice
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Models, Neurological
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Neurons / physiology*
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Oligodendroglia / metabolism
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Rats
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Stem Cells / physiology*
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Trans-Activators / metabolism
Substances
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Hedgehog Proteins
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Trans-Activators