Abstract
Gap junctions are abundant in the mammalian retina and many neuronal types form neural networks. Several different neuronal connexins have now been identified in the mammalian retina. Cx36 supports coupling in the AII amacrine cell network and is essential for processing rod signals. Cx36 is probably also responsible for photoreceptor coupling. Horizontal cells appear to be extensively coupled by either Cx50 or Cx57. These results indicate that multiple neuronal connexins are expressed in the mammalian retina and that different cell types express different connexins.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Amacrine Cells / cytology
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Amacrine Cells / metabolism*
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Amacrine Cells / physiology
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Animals
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Biotin / analogs & derivatives*
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Biotin / metabolism
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Connexins / metabolism*
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Eye Proteins / metabolism*
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Gap Junction delta-2 Protein
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Gap Junctions / metabolism
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Gap Junctions / physiology
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Retina / cytology
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Retina / metabolism*
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Retina / physiology
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Retinal Rod Photoreceptor Cells / cytology
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Retinal Rod Photoreceptor Cells / metabolism*
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Retinal Rod Photoreceptor Cells / physiology
Substances
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Connexins
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Eye Proteins
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connexin 50
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neurobiotin
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Biotin