Abstract
The GGA proteins are a family of ubiquitously expressed, Arf-dependent clathrin adaptors that mediate the sorting of mannose-6-phosphate receptors between the trans-Golgi network and endosomes. Recent studies have elucidated the biochemical and structural bases for the interaction of the GGA proteins with many binding partners, and have shed light on the molecular and cellular mechanisms by which the GGA proteins participate in protein sorting.
MeSH terms
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ADP-Ribosylation Factors / chemistry*
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ADP-Ribosylation Factors / genetics
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ADP-Ribosylation Factors / physiology*
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Adaptor Proteins, Vesicular Transport*
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Amino Acid Sequence
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Animals
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Binding Sites
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Carrier Proteins / chemistry*
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Carrier Proteins / genetics
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Carrier Proteins / physiology*
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Endosomes / physiology
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Humans
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Models, Molecular
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Protein Conformation
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Protein Transport
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Receptor, IGF Type 2 / physiology
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Saccharomyces cerevisiae / genetics
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Sequence Alignment
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Sequence Homology, Amino Acid
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trans-Golgi Network / physiology
Substances
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Adaptor Proteins, Vesicular Transport
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Carrier Proteins
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GGA adaptor proteins
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Receptor, IGF Type 2
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ADP-Ribosylation Factors