Abstract
Site-specific recombinase systems (Cre-loxP, Flp-FRT, and phi C31-att) are transforming both forward and reverse genetics in mice. By enabling high-fidelity DNA modifications to be induced in vitro or in vivo, these systems have incited a wave of new biology, advancing our understanding of gene function, genetic relationships, development, and disease.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cell Lineage / genetics
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DNA Nucleotidyltransferases / genetics
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Gene Expression Regulation / genetics*
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Genome*
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Integrases / genetics
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Mice / genetics*
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Models, Animal
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Molecular Biology / methods*
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Molecular Biology / trends
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Mutagenesis, Site-Directed / genetics
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Recombinases / genetics*
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Recombination, Genetic / genetics*
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Viral Proteins / genetics
Substances
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Recombinases
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Viral Proteins
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Cre recombinase
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DNA Nucleotidyltransferases
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FLP recombinase
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Integrases