Abstract
In the CA3 region of the hippocampus, extensive recurrent associational/commissural (A/C) connections made by pyramidal cells may function as a network for associative memory storage and recall. We here report that long-term potentiation (LTP) at the A/C synapses can be induced by association of brief spike trains in mossy fibers (MFs) from the dentate gyrus and A/C fibers. This LTP not only required substantial overlap between spike trains in MFs and A/C fibers, but also depended on the temporal order of these spike trains in a manner not predicted by the well-known rule of spike timing-dependent plasticity and requiring activation of type 1 metabotropic glutamate receptors. Importantly, spike trains in a putative single MF input provided effective postsynaptic activity for the induction of LTP at A/C synapses. Thus, the timing of spike trains in individual MFs may code information that is crucial for the associative modification of CA3 recurrent synapses.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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2-Amino-5-phosphonovalerate / pharmacology
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Action Potentials / drug effects
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Action Potentials / physiology*
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Animals
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Animals, Newborn
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Chromones / pharmacology
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Dose-Response Relationship, Radiation
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Electric Stimulation
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Excitatory Amino Acid Agonists / pharmacology
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Excitatory Amino Acid Antagonists / pharmacology
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Excitatory Postsynaptic Potentials / physiology
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Hippocampus / cytology*
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In Vitro Techniques
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Long-Term Potentiation / drug effects
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Long-Term Potentiation / physiology
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Models, Neurological
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Mossy Fibers, Hippocampal / physiology*
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N-Methylaspartate / pharmacology
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Neuronal Plasticity
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Pyramidal Cells / drug effects
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Pyramidal Cells / physiology*
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Rats
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Rats, Sprague-Dawley
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Synapses / drug effects
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Synapses / physiology*
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Synaptic Transmission
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Time Factors
Substances
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7-(hydroxyimino)cyclopropan(b)chromen-1a-carbxoylic acid ethyl ester
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Chromones
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Excitatory Amino Acid Agonists
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Excitatory Amino Acid Antagonists
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N-Methylaspartate
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2-Amino-5-phosphonovalerate