Abstract
Cytokine-mediated inflammation is a target for novel therapies as well as for fundamental research. A single amino acid mutation in the NALP-3 gene controlling the activation of caspase-1 results in increased processing of the inactive IL-1beta precursor and release of the active cytokine. Blocking IL-1 receptors arrests inflammation in humans with the mutation.
MeSH terms
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Autoimmune Diseases / immunology
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Carrier Proteins / genetics
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Carrier Proteins / metabolism*
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Caspase 1 / metabolism
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Humans
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Inflammation / immunology*
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Interleukin-1 / metabolism*
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Macromolecular Substances
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Models, Immunological
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Monocytes / immunology
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Mutation
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NLR Family, Pyrin Domain-Containing 3 Protein
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Protein Precursors / metabolism*
Substances
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Carrier Proteins
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Interleukin-1
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Macromolecular Substances
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NLR Family, Pyrin Domain-Containing 3 Protein
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NLRP3 protein, human
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Protein Precursors
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interleukin 1 precursor
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Caspase 1