Abstract
We have characterized for the first time the mouse expression patterns of the three known members of the novel RGM gene family ('Repulsive Axonal Guidance molecules' A, B and C) by in situ hybridization. Both RGM A and B are mostly expressed in central nervous system, while RGM C is exclusively expressed in all striated muscle and in the myocardium. RGM A and B appear at every level of the developing neural axis, where they colocalize to a large extent in the mantle layer, although only RGM A appears in the neuroepithelium, and only RGM B in the peripheral nervous system. During development, both RGM A and B appear also in lung and in limb cartilage, while RGM B has additional expression domains in pancreas.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cartilage / embryology
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Cartilage / growth & development
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Cartilage / metabolism
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Cell Adhesion Molecules, Neuronal
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GPI-Linked Proteins
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In Situ Hybridization
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Lung / embryology
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Lung / growth & development
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Lung / metabolism
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Mice / embryology*
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Mice / growth & development*
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Mice / metabolism
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Muscle Proteins / biosynthesis*
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Muscle Proteins / genetics
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Muscle, Skeletal / embryology
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Muscle, Skeletal / growth & development
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Muscle, Skeletal / metabolism
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Myocardium / metabolism
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Nerve Tissue Proteins / biosynthesis*
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Nerve Tissue Proteins / genetics
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Nervous System / embryology
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Nervous System / growth & development
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Nervous System / metabolism
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Pancreas / embryology
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Pancreas / growth & development
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Pancreas / metabolism
Substances
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Cell Adhesion Molecules, Neuronal
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GPI-Linked Proteins
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Muscle Proteins
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Nerve Tissue Proteins
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Rgma protein, mouse
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Rgmb protein, mouse
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Rgmc protein, mouse