Abstract
Ski and SnoN are unique proto-oncoproteins in that they can induce both oncogenic transformation and terminal muscle differentiation when expressed at high levels. Recent studies using in vitro and in vivo approaches have begun to unravel the complex roles of Ski and SnoN in tumorigenesis and embryonic development. The identification of Ski and SnoN as important negative regulators of signal transduction by the transforming growth factor-beta superfamily of cytokines provides a valuable molecular basis for the complex functions of Ski and SnoN.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Cell Lineage / physiology
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DNA-Binding Proteins / antagonists & inhibitors
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DNA-Binding Proteins / metabolism
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DNA-Binding Proteins / physiology*
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Gene Expression Regulation, Developmental*
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Humans
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Intracellular Signaling Peptides and Proteins
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Muscle, Skeletal / metabolism
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Neurons / metabolism
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Proto-Oncogene Proteins / metabolism
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Proto-Oncogene Proteins / physiology*
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Signal Transduction*
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Smad Proteins
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Trans-Activators / antagonists & inhibitors
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Transforming Growth Factor beta / metabolism*
Substances
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DNA-Binding Proteins
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Intracellular Signaling Peptides and Proteins
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Proto-Oncogene Proteins
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SKIL protein, human
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Smad Proteins
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Trans-Activators
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Transforming Growth Factor beta
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SKI protein, human