PGC-1alpha: turbocharging mitochondria

Cell. 2004 Oct 1;119(1):5-7. doi: 10.1016/j.cell.2004.09.016.

Abstract

PGC-1alpha plays essential and diverse functions in the control of metabolism ranging from mitochondrial biogenesis and respiration to hepatic gluconeogenesis and muscle fiber-type switching. In a paper in this issue of Cell, the characterization of PGC-1alpha(-/-) mice illustrates these pleiotropic functions and reveals an unexpected role for PGC-1alpha in the brain.

Publication types

  • Review
  • Comment

MeSH terms

  • Animals
  • Brain / metabolism
  • Brain / physiopathology
  • Cell Respiration / genetics*
  • Disease Models, Animal
  • Energy Metabolism / genetics*
  • Humans
  • Mice
  • Mitochondria / genetics
  • Mitochondria / metabolism*
  • Muscle, Skeletal / metabolism
  • Muscle, Skeletal / physiopathology
  • Neurodegenerative Diseases / genetics
  • Neurodegenerative Diseases / metabolism
  • Neurodegenerative Diseases / physiopathology
  • Organ Specificity
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
  • Trans-Activators / deficiency*
  • Trans-Activators / genetics
  • Transcription Factors

Substances

  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
  • Ppargc1a protein, mouse
  • Trans-Activators
  • Transcription Factors