Abstract
PGC-1alpha plays essential and diverse functions in the control of metabolism ranging from mitochondrial biogenesis and respiration to hepatic gluconeogenesis and muscle fiber-type switching. In a paper in this issue of Cell, the characterization of PGC-1alpha(-/-) mice illustrates these pleiotropic functions and reveals an unexpected role for PGC-1alpha in the brain.
MeSH terms
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Animals
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Brain / metabolism
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Brain / physiopathology
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Cell Respiration / genetics*
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Disease Models, Animal
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Energy Metabolism / genetics*
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Humans
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Mice
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Mitochondria / genetics
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Mitochondria / metabolism*
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Muscle, Skeletal / metabolism
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Muscle, Skeletal / physiopathology
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Neurodegenerative Diseases / genetics
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Neurodegenerative Diseases / metabolism
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Neurodegenerative Diseases / physiopathology
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Organ Specificity
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Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
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Trans-Activators / deficiency*
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Trans-Activators / genetics
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Transcription Factors
Substances
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Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
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Ppargc1a protein, mouse
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Trans-Activators
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Transcription Factors