Direct evidence for expression of dopamine receptors in astrocytes from basal ganglia

Ikuko Miyazaki; Masato Asanuma; Francisco J Diaz-Corrales; Ko Miyoshi; Norio Ogawa

doi:10.1016/j.brainres.2004.09.014

Direct evidence for expression of dopamine receptors in astrocytes from basal ganglia

Brain Res. 2004 Dec 10;1029(1):120-3. doi: 10.1016/j.brainres.2004.09.014.

Authors

Ikuko Miyazaki¹, Masato Asanuma, Francisco J Diaz-Corrales, Ko Miyoshi, Norio Ogawa

Affiliation

¹ Department of Brain Science, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikatacho, Okayama 700-8558, Japan.

PMID: 15533323
DOI: 10.1016/j.brainres.2004.09.014

Abstract

Expression of dopamine receptors (DA-Rs) in astrocytes was examined in vitro and in vivo using primary cultured astrocytes and brain slices from rat basal ganglia. Astrocytes from basal ganglia expressed DA D1-, D3-, D4- and D5-receptors and D4-mediated signal transduction in response to DA, suggesting possible involvement of astrocytes in the pharmacological action of atypical antipsychotic drugs and in DA response in some neurological diseases.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Astrocytes / metabolism*
Basal Ganglia / cytology*
Basal Ganglia / metabolism
Cyclic AMP Response Element-Binding Protein / metabolism
RNA, Messenger / analysis
Rats
Rats, Sprague-Dawley
Receptors, Dopamine / classification
Receptors, Dopamine / genetics
Receptors, Dopamine / metabolism*

Substances

Cyclic AMP Response Element-Binding Protein
RNA, Messenger
Receptors, Dopamine