Abstract
Epidemiological studies have consistently demonstrated an inverse association between coffee consumption and Parkinson's disease (PD). This study was designed to investigate the beneficial effect of caffeine at a dose comparable to that of human exposure in a model of PD. For this purpose, unilateral intrastriatal 6-hydroxydopamine (6-OHDA)-lesioned rats were pretreated with caffeine (20 mg/kg; i.p.) 1 h before surgery and treated twice a day (10 mg/kg) for 1 month. Apomorphine-induced rotations and number of Nissl-stained neurons of substantia nigra pars compacta (SNC) were counted. The results demonstrated that caffeine administration for 1 month could attenuate the rotational behavior in lesioned rats and protect the neurons of SNC against 6-OHDA toxicity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antiparkinson Agents / pharmacology
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Apomorphine / pharmacology
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Behavior, Animal / drug effects
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Behavior, Animal / physiology*
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Caffeine / therapeutic use*
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Cell Count
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Central Nervous System Stimulants / therapeutic use*
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Functional Laterality / physiology
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Male
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Nerve Degeneration / pathology
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Nerve Degeneration / prevention & control*
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Nerve Degeneration / psychology
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Neurons / pathology
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Parkinson Disease, Secondary / pathology
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Parkinson Disease, Secondary / prevention & control*
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Parkinson Disease, Secondary / psychology
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Rats
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Rats, Wistar
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Rotation
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Stereotyped Behavior / drug effects
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Substantia Nigra / pathology
Substances
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Antiparkinson Agents
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Central Nervous System Stimulants
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Caffeine
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Apomorphine