Abstract
Major depression is conditionally linked to a polymorphism of the human serotonin transporter gene (SLC6A4). During the presentation of aversive, but not pleasant, pictures, healthy carriers of the SLC6A4 short (s) allele showed stronger activation of the amygdala on functional magnetic resonance imaging. s carriers also showed greater coupling between the amygdala and the ventromedial prefrontal cortex, which may contribute to the abnormally high activity in the amygdala and medial prefrontal cortex seen in major depression.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Alleles*
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Amygdala / blood supply
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Amygdala / physiology*
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Emotions
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Heterozygote*
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Humans
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Magnetic Resonance Imaging
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Male
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Membrane Glycoproteins / genetics
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Membrane Glycoproteins / physiology*
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Membrane Transport Proteins / genetics
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Membrane Transport Proteins / physiology*
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Middle Aged
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Nerve Tissue Proteins / genetics
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Nerve Tissue Proteins / physiology*
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Oxygen / blood
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Photic Stimulation
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Prefrontal Cortex / blood supply
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Prefrontal Cortex / physiology*
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Serotonin Plasma Membrane Transport Proteins
Substances
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Membrane Glycoproteins
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Membrane Transport Proteins
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Nerve Tissue Proteins
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SLC6A4 protein, human
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Serotonin Plasma Membrane Transport Proteins
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Oxygen