N. Popeski and B. Woodside (2004) report that the injection of L-NAME into the 3rd ventricle, which would suppress the synthesis of nitric oxide, disrupts both maternal retrieval of pups and maternal aggression in postpartum rats. These findings are discussed around the question of whether a single central integrative site regulates retrieval and maternal aggression or whether independent neural mechanisms, each dependent upon nitric oxide, regulate the 2 behaviors. A case is made for each point of view. Future research utilizing direct injections of L-NAME into specific neural sites is needed to resolve this important question.