Abstract
The small GTPase Rap1 is involved in several aspects of cell adhesion, including integrin-mediated cell adhesion and cadherin-mediated cell junction formation. Recently, several effector proteins for Rap1 have been identified providing a clear link between Rap1 and actin dynamics. Furthermore, evidence is accumulating that Rap1 functions in the spatial and temporal control of cell polarity.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Actin Cytoskeleton / metabolism*
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Animals
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Cell Adhesion / physiology
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Cell Membrane / metabolism*
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Cell Polarity / physiology*
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Humans
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Models, Biological
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Second Messenger Systems / physiology
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Signal Transduction / physiology*
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rap1 GTP-Binding Proteins / genetics
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rap1 GTP-Binding Proteins / metabolism*
Substances
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rap1 GTP-Binding Proteins