Abstract
Ten-day-old rat pups (P10) subjected to acute hypoxia (down to 4% O2) had as adults increased aggression (handling test), memory impairment (water maze test), and decreased CA1 cell counts. Pups subjected to chronic hypoxia (10% O2 from P0 to P21) had increased aggression, hyperactivity (open-field test), and decreased CA1 cell counts. Chronic hypoxia with superimposed acute hypoxia resulted in consequences that were not different from those of chronic hypoxia.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Analysis of Variance
-
Animals
-
Animals, Newborn
-
Behavior, Animal / physiology*
-
Cell Count / methods
-
Cell Death / physiology
-
Chronic Disease
-
Enzyme-Linked Immunosorbent Assay
-
Erythropoietin / blood
-
Exploratory Behavior / physiology
-
Hippocampus* / growth & development
-
Hippocampus* / pathology
-
Hippocampus* / physiopathology
-
Hypoxia / blood
-
Hypoxia / pathology*
-
Hypoxia / physiopathology*
-
In Situ Nick-End Labeling / methods
-
Maze Learning / physiology
-
Rats
-
Rats, Sprague-Dawley
-
Time Factors
-
Time*