Abstract
Parkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic neurons in the substantia nigra. Although the etiology of PD is incompletely understood, the recent discovery of genes associated with rare monogenic forms of the disease, together with earlier studies and new experimental animal models, has provided important and novel insight into the molecular pathways involved in disease pathogenesis. Increasing evidence indicates that deficits in mitochondrial function, oxidative and nitrosative stress, the accumulation of aberrant or misfolded proteins, and ubiquitin-proteasome system dysfunction may represent the principal molecular pathways or events that commonly underlie the pathogenesis of sporadic and familial forms of PD .
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Humans
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Intracellular Signaling Peptides and Proteins
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Models, Biological
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Mutation
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Nerve Tissue Proteins / chemistry
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Nerve Tissue Proteins / genetics
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Oncogene Proteins / genetics
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Oncogene Proteins / metabolism
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Parkinson Disease / genetics*
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Parkinson Disease / metabolism
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Proteasome Endopeptidase Complex / metabolism
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Protein Deglycase DJ-1
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Protein Kinases / genetics
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Protein Kinases / metabolism
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Signal Transduction / physiology
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Synucleins
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Ubiquitin / genetics
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Ubiquitin / metabolism
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Ubiquitin Thiolesterase / genetics
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Ubiquitin Thiolesterase / metabolism
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Ubiquitin-Protein Ligases / genetics
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Ubiquitin-Protein Ligases / metabolism
Substances
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Intracellular Signaling Peptides and Proteins
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Nerve Tissue Proteins
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Oncogene Proteins
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Synucleins
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UCHL1 protein, human
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Ubiquitin
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Ubiquitin-Protein Ligases
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parkin protein
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Protein Kinases
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PTEN-induced putative kinase
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PARK7 protein, human
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Protein Deglycase DJ-1
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Ubiquitin Thiolesterase
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Proteasome Endopeptidase Complex