Injury reactive myelin/oligodendrocyte-derived axon growth inhibition in the adult mammalian central nervous system

Jan M Schwab; Frédéric Bernard; Caroline Moreau-Fauvarque; Alain Chédotal

doi:10.1016/j.brainresrev.2004.10.007

Injury reactive myelin/oligodendrocyte-derived axon growth inhibition in the adult mammalian central nervous system

Brain Res Brain Res Rev. 2005 Sep;49(2):295-9. doi: 10.1016/j.brainresrev.2004.10.007.

Authors

Jan M Schwab¹, Frédéric Bernard, Caroline Moreau-Fauvarque, Alain Chédotal

Affiliation

¹ CNRS UMR 7102, Equipe Développement Neuronal, Université Pierre et Marie Curie (Paris 6), Batiment B, Case 12, 9 Quai Saint Bernard, 75005 Paris, France.

PMID: 16111557
DOI: 10.1016/j.brainresrev.2004.10.007

Abstract

Myelin inhibition is considered a constitutive, static, repulsive barrier not reactive to a central nervous system (CNS) lesion. However, recent evidence underlines the existence of considerable add-on axon growth inhibition upon CNS injury. This postlesional, reactive myelin/oligodendrocyte-derived inhibition will require the development of novel screening approaches and therapeutic reagents to promote axonal regeneration.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Axons / physiology*
Central Nervous System Diseases / pathology*
Central Nervous System Diseases / physiopathology*
Gene Expression Regulation
Models, Neurological
Myelin Proteins / metabolism*
Myelin-Associated Glycoprotein
Nerve Regeneration
Oligodendroglia / metabolism*
Signal Transduction

Substances

Myelin Proteins
Myelin-Associated Glycoprotein