Abstract
L7-PKCI transgenic mice, which lack parallel fiber-Purkinje cell long-term depression (LTD), were tested with two different mazes to dissociate the relative importance of declarative and procedural components of spatial navigation. We show that L7-PKCI mice are deficient in acquisition of an adapted goal-oriented behavior, part of the procedural component of the task. This supports the hypothesis that cerebellar LTD may subserve a general sensorimotor adaptation process shared by motor and spatial learning functions.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adaptation, Physiological / genetics
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Adaptation, Physiological / physiology*
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Analysis of Variance
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Animals
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Behavior, Animal
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Cerebellum / cytology*
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Escape Reaction / physiology
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Long-Term Synaptic Depression / physiology*
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Maze Learning / physiology
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Mice
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Mice, Inbred C57BL
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Mice, Transgenic
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Perceptual Disorders / genetics
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Perceptual Disorders / physiopathology*
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Protein Kinase C / genetics
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Psychomotor Performance / physiology
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Purkinje Cells / physiology*
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Reaction Time / genetics
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Spatial Behavior / physiology*
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Time Factors