Abstract
We isolated a new gene which shares all the features of the Ly-6/neurotoxin superfamily, from gene organization to predicted 3D structure. As it is preferentially expressed in the nervous system, we called this gene lynx2, by analogy with lynx1, a nAChR modulator. In embryonic and postnatal mouse, lynx2 is expressed in postmitotic central and peripheral neurons. These include subpopulations of motor neurons, sensory neurons, interneurons and neurons of the autonomous nervous system. In addition, lynx2 is transiently expressed around the growing nerves in the limb bud. Comparison of its spatio-temporal expression pattern with that of two other members of this family, lynx1 and ly-6h, shows that these genes are detected both in distinct and overlapping neuron populations.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adaptor Proteins, Signal Transducing
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Amino Acid Sequence
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Animals
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Biomarkers / metabolism
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Embryo, Mammalian / anatomy & histology
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Embryo, Mammalian / physiology*
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In Situ Hybridization
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Intermediate Filament Proteins / genetics
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Intermediate Filament Proteins / metabolism
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Membrane Glycoproteins / chemistry
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Membrane Glycoproteins / genetics
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Membrane Glycoproteins / metabolism*
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Mice
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Mice, Transgenic
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Models, Molecular
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Molecular Sequence Data
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Morphogenesis*
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Nerve Tissue Proteins / genetics
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Nerve Tissue Proteins / metabolism
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Neurons / cytology
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Neurons / physiology*
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Neuropeptides / chemistry
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Neuropeptides / genetics
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Neuropeptides / metabolism*
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Peripherins
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Protein Structure, Tertiary
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Sequence Alignment
Substances
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Adaptor Proteins, Signal Transducing
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Biomarkers
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Intermediate Filament Proteins
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Lynx1 protein, mouse
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Lynx2 protein, mouse
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Membrane Glycoproteins
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Nerve Tissue Proteins
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Neuropeptides
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Peripherins