Abstract
The actions of the neuropeptide corticotropin-releasing factor (CRF) are modulated by a CRF binding protein (CRFBP). In view of the memory-enhancing effects of CRF, the release of endogenous CRF from CRFBP by CRFBP inhibitors has been suggested as a therapeutical strategy for the treatment of cognitive deficits. This mini-review will summarize recent advances in the field with a focus on the pharmaceutical potential of CRFBP inhibitors.
MeSH terms
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Amino Acid Sequence
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Animals
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Binding Sites
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Carrier Proteins / antagonists & inhibitors
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Carrier Proteins / chemistry
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Cognition Disorders / drug therapy
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Corticotropin-Releasing Hormone / chemistry
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Corticotropin-Releasing Hormone / metabolism*
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Humans
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Ligands
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Molecular Sequence Data
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Receptors, Corticotropin-Releasing Hormone / chemistry
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Receptors, Corticotropin-Releasing Hormone / metabolism*
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Urocortins
Substances
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Carrier Proteins
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Ligands
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Receptors, Corticotropin-Releasing Hormone
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Urocortins
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corticotropin releasing factor-binding protein
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Corticotropin-Releasing Hormone