Human neocortical oscillations exhibit theta phase differences between encoding and retrieval

Neuroimage. 2006 Jul 1;31(3):1352-8. doi: 10.1016/j.neuroimage.2006.01.009. Epub 2006 Mar 15.

Abstract

We analyzed intracranial brain activity recorded from human participants during the performance of a working-memory task. We show that 6-13 Hz activity exhibits consistent phase across trials following experimental stimuli, and that this phase significantly differs between study and test stimuli. These findings suggest that oscillatory phase reflects the encoding-retrieval state of neural networks, supporting predictions of recent models of memory.[Hasselmo, M.E., Wyble, B.P., and Bodelon, C., 2002. A proposed function for hippocampal theta rhythm: Separate phases of encoding and retrieval enhance reversal of prior learning. Neural Comput. 14 793-817.; Judge, S.J., Hasselmo, M.E., 2004. Theta rhythmic stimulation of stratum lacunosum-moleculare in rat hippocampus contributes to associative LTP at a phase offset in stratum radiatum. J. Neurophys. 92 1516-1624.].

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Adult
  • Brain Mapping
  • Child
  • Electrodes, Implanted
  • Electroencephalography*
  • Epilepsy, Temporal Lobe / physiopathology
  • Female
  • Fourier Analysis
  • Hippocampus / physiopathology
  • Humans
  • Image Processing, Computer-Assisted*
  • Imaging, Three-Dimensional*
  • Magnetic Resonance Imaging*
  • Male
  • Memory, Short-Term / physiology*
  • Neocortex / physiopathology*
  • Nerve Net / physiopathology*
  • Oscillometry*
  • Reaction Time / physiology
  • Reference Values
  • Signal Processing, Computer-Assisted*
  • Theta Rhythm*
  • Verbal Learning / physiology*