Abstract
Postnatal glutamatergic principal neuron synapses are typically presumed to express only calcium-impermeable (CI), GluR2-containing AMPARs under physiological conditions. Here, however, we demonstrate that long-term potentiation (LTP) in CA1 hippocampal pyramidal neurons causes rapid incorporation of GluR2-lacking calcium-permeable (CP)-AMPARs: CP-AMPARs are present transiently, being replaced by GluR2-containing AMPARs approximately 25 min after LTP induction. Thus, CP-AMPARs are physiologically expressed at CA1 pyramidal cell synapses during LTP, and may be required for LTP consolidation.
Publication types
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Comparative Study
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Research Support, N.I.H., Intramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Animals, Newborn
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Calcium / metabolism
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Dose-Response Relationship, Radiation
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Electric Stimulation / methods
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Excitatory Postsynaptic Potentials / drug effects
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Excitatory Postsynaptic Potentials / physiology
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Excitatory Postsynaptic Potentials / radiation effects
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Hippocampus / cytology*
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In Vitro Techniques
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Long-Term Potentiation / drug effects
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Long-Term Potentiation / physiology*
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Long-Term Potentiation / radiation effects
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Mice
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Nicotinic Antagonists / pharmacology
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Patch-Clamp Techniques / methods
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Polyamines / pharmacology
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Pyramidal Cells / drug effects
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Pyramidal Cells / physiology*
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Pyramidal Cells / radiation effects
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Rats
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Receptors, AMPA / chemistry
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Receptors, AMPA / deficiency
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Receptors, AMPA / physiology*
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Time Factors
Substances
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Nicotinic Antagonists
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Polyamines
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Receptors, AMPA
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delta-philanthotoxin
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glutamate receptor ionotropic, AMPA 2
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Calcium