Abstract
Intracellular injection of QX-314 blocked the ability of baclofen and 5-carboxyamidotryptamine to hyperpolarize cells in the rat hippocampus. This effect was not associated with a reduction in the effects of norepinephrine on these cells nor a blockade of the potassium channels underlying the calcium-dependent afterhyperpolarization responsible or significant changes in membrane potential. These results suggest that QX-314 is an effective blocker of G-protein-gated potassium channels in this region.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Baclofen / antagonists & inhibitors*
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Calcium
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Hippocampus / cytology
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Hippocampus / drug effects*
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Hippocampus / metabolism
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Lidocaine / analogs & derivatives*
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Lidocaine / pharmacology
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Membrane Potentials / drug effects
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Norepinephrine / pharmacology
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Potassium Channels / drug effects*
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Rats
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Receptors, GABA-A / physiology
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Receptors, Serotonin / physiology
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Serotonin / analogs & derivatives*
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Serotonin / pharmacology
Substances
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Potassium Channels
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Receptors, GABA-A
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Receptors, Serotonin
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QX-314
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Serotonin
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5-carboxamidotryptamine
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Lidocaine
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Baclofen
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Calcium
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Norepinephrine