Abstract
Environmental enrichment increases adult hippocampal neurogenesis and alters hippocampal-dependent behavior in rodents. To investigate a causal link between these two observations, we analyzed the effect of enrichment on spatial learning and anxiety-like behavior while blocking adult hippocampal neurogenesis. We report that environmental enrichment alters behavior in mice regardless of their hippocampal neurogenic capability, providing evidence that the newborn cells do not mediate these effects of enrichment.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Antidepressive Agents / pharmacology
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Anxiety / drug therapy
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Anxiety / physiopathology
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Behavior, Animal / drug effects
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Behavior, Animal / physiology
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Behavior, Animal / radiation effects
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Bromodeoxyuridine
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Cell Division / drug effects
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Cell Division / physiology
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Cell Division / radiation effects
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Cell Proliferation / radiation effects*
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Dentate Gyrus / drug effects
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Dentate Gyrus / physiology*
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Dentate Gyrus / radiation effects
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Environment, Controlled
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Feeding Behavior / drug effects
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Feeding Behavior / physiology
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Feeding Behavior / radiation effects
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Habituation, Psychophysiologic / drug effects
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Habituation, Psychophysiologic / physiology
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Habituation, Psychophysiologic / radiation effects
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Maze Learning / drug effects
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Maze Learning / physiology*
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Maze Learning / radiation effects
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Memory Disorders / physiopathology
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Mice
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Neuronal Plasticity / drug effects
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Neuronal Plasticity / physiology*
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Neuronal Plasticity / radiation effects
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Neurons / drug effects
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Neurons / physiology*
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Neurons / radiation effects
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Stem Cells / drug effects
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Stem Cells / physiology
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Stem Cells / radiation effects
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X-Rays
Substances
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Antidepressive Agents
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Bromodeoxyuridine