Players in the PARP-1 cell-death pathway: JNK1 joins the cast

Conrad C Alano; Raymond A Swanson

doi:10.1016/j.tibs.2006.04.006

Players in the PARP-1 cell-death pathway: JNK1 joins the cast

Trends Biochem Sci. 2006 Jun;31(6):309-11. doi: 10.1016/j.tibs.2006.04.006. Epub 2006 May 6.

Authors

Conrad C Alano¹, Raymond A Swanson

Affiliation

¹ Department of Neurology, University of California and Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA.

PMID: 16679020
DOI: 10.1016/j.tibs.2006.04.006

Abstract

The nuclear enzyme poly(ADP-ribose) polymerase-1 (PARP-1) triggers a cell-death pathway in which mitochondria play an integral part, but it remains uncertain how PARP-1 activation in the nucleus is signaled to the mitochondria. A recent report by Xu and colleagues suggests that Jun kinase-1, a member of the mitogen-activated protein kinase family, might have a crucial role in this signaling pathway.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Cell Death / physiology
Cell Nucleus / metabolism*
Enzyme Activation / physiology
Humans
Mitochondria / metabolism*
Mitogen-Activated Protein Kinase 8 / metabolism*
Poly (ADP-Ribose) Polymerase-1
Poly(ADP-ribose) Polymerases / metabolism*
Signal Transduction / physiology*

Substances

PARP1 protein, human
Poly (ADP-Ribose) Polymerase-1
Poly(ADP-ribose) Polymerases
Mitogen-Activated Protein Kinase 8

Grants and funding

NS41421/NS/NINDS NIH HHS/United States