Isolation and characterization of a novel cDNA clone encoding a homeodomain that is developmentally regulated in the ventral forebrain

Neuron. 1991 Aug;7(2):221-9. doi: 10.1016/0896-6273(91)90260-7.

Abstract

A complementary DNA, Tes-1, of a novel homeodomain protein has been cloned, and its pattern of expression has been characterized. It is a structural homolog of Distal-less, a homeodomain-encoding gene in D. melanogaster. Its expression is developmentally regulated and is limited to structures in the head. Within the central nervous system of the midgestation mouse embryo, it is expressed exclusively in the ventral forebrain. It is likely that Tes-1 plays a regulatory role in the development of this complex neural structure.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Brain / embryology
  • Brain / metabolism*
  • Brain / physiology
  • Cloning, Molecular
  • DNA / genetics*
  • DNA / isolation & purification
  • DNA / metabolism
  • Female
  • Genes, Homeobox / genetics*
  • Mice
  • Mice, Inbred BALB C
  • Molecular Sequence Data
  • Pregnancy
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Transcription, Genetic / genetics

Substances

  • RNA, Messenger
  • DNA

Associated data

  • GENBANK/M80540
  • GENBANK/S61932
  • GENBANK/S61935
  • GENBANK/S70258
  • GENBANK/S70261
  • GENBANK/S70262
  • GENBANK/X57453
  • GENBANK/X57454
  • GENBANK/X57455
  • GENBANK/X63253