Nogo-A-specific antibody treatment enhances sprouting and functional recovery after cervical lesion in adult primates

Patrick Freund; Eric Schmidlin; Thierry Wannier; Jocelyne Bloch; Anis Mir; Martin E Schwab; Eric M Rouiller

doi:10.1038/nm1436

Nogo-A-specific antibody treatment enhances sprouting and functional recovery after cervical lesion in adult primates

Nat Med. 2006 Jul;12(7):790-2. doi: 10.1038/nm1436. Epub 2006 Jul 2.

Authors

Patrick Freund¹, Eric Schmidlin, Thierry Wannier, Jocelyne Bloch, Anis Mir, Martin E Schwab, Eric M Rouiller

Affiliation

¹ Unit of Physiology and Program in Neurosciences, Department of Medicine, Faculty of Sciences, University of Fribourg, Chemin du Musée 5, CH-1700 Fribourg, Switzerland.

PMID: 16819551
DOI: 10.1038/nm1436

Abstract

In rodents, after spinal lesion, neutralizing the neurite growth inhibitor Nogo-A promotes axonal sprouting and functional recovery. To evaluate this treatment in primates, 12 monkeys were subjected to cervical lesion. Recovery of manual dexterity and sprouting of corticospinal axons were enhanced in monkeys treated with Nogo-A-specific antibody as compared to monkeys treated with control antibody.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antibodies / therapeutic use*
Cervix Uteri / physiopathology
Disease Models, Animal
Female
Macaca
Motor Activity / drug effects*
Myelin Proteins / immunology*
Nogo Proteins
Uterine Cervical Diseases / immunology*

Substances

Antibodies
Myelin Proteins
Nogo Proteins