The mGluR2/3 agonist LY379268 attenuates context- and discrete cue-induced reinstatement of sucrose seeking but not sucrose self-administration in rats

Jennifer M Bossert; Gabriela C Poles; Sean I Sheffler-Collins; Udi E Ghitza

doi:10.1016/j.bbr.2006.06.008

The mGluR2/3 agonist LY379268 attenuates context- and discrete cue-induced reinstatement of sucrose seeking but not sucrose self-administration in rats

Behav Brain Res. 2006 Oct 2;173(1):148-52. doi: 10.1016/j.bbr.2006.06.008. Epub 2006 Jul 10.

Authors

Jennifer M Bossert¹, Gabriela C Poles, Sean I Sheffler-Collins, Udi E Ghitza

Affiliation

¹ Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, NIH/DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA. jbossert@intra.nida.nih.gov

PMID: 16834996
DOI: 10.1016/j.bbr.2006.06.008

Abstract

We recently reported that systemic injections of the mGluR(2/3) agonist LY379268, which decreases evoked glutamate release, attenuate context- and discrete cue-induced reinstatement of heroin seeking, but not heroin self-administration. Here, we report that systemic injections of LY379268 attenuate context- and discrete cue-induced reinstatement of sucrose seeking, but not sucrose self-administration. These results suggest that similar neuronal mechanisms mediate cue-induced relapse to opiate- and palatable food seeking.

Publication types

Comparative Study
Research Support, N.I.H., Intramural

MeSH terms

Amino Acids / pharmacology*
Animals
Appetitive Behavior / drug effects*
Behavior, Addictive / physiopathology*
Bridged Bicyclo Compounds, Heterocyclic / pharmacology*
Feeding Behavior / drug effects*
Male
Rats
Receptors, Metabotropic Glutamate / agonists*
Reinforcement, Psychology
Self Administration
Sucrose / administration & dosage

Substances

Amino Acids
Bridged Bicyclo Compounds, Heterocyclic
LY 379268
Receptors, Metabotropic Glutamate
metabotropic glutamate receptor 2
Sucrose

Grants and funding

Intramural NIH HHS/United States