Abstract
N-Methyl-D-aspartate (NMDA) or aspartate (Asp) increased the cytosolic free calcium concentration ([Ca]in) in some populations of Purkinje cells dissociated from immature rat cerebellum. The NMDA- and Asp-induced rise in [Ca]in was affected only a little by adding glycine or NMDA antagonists, but was reduced either by adding Mg2+, Gallopamil hydrochloride (D-600) and gamma-amino-butyric acid, or by removing external Na+. The results suggest that stimulation of the NMDA-sensitive receptors transiently expressed on immature Purkinje cell soma results in a rise in [Ca]in through the activation of voltage-dependent Ca2+ channels.
MeSH terms
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2-Amino-5-phosphonovalerate / pharmacology
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6-Cyano-7-nitroquinoxaline-2,3-dione
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Aging
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Animals
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Animals, Newborn
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Aspartic Acid / pharmacology*
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Calcium / metabolism
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Cerebellum / growth & development*
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Cytosol / drug effects
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Cytosol / metabolism
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Gallopamil / pharmacology
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Glycine / pharmacology
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In Vitro Techniques
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Magnesium / pharmacology
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N-Methylaspartate / pharmacology*
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Organophosphorus Compounds / pharmacology
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Piperazines / pharmacology
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Purkinje Cells / drug effects
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Purkinje Cells / metabolism*
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Quinoxalines / pharmacology
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Rats
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Rats, Inbred Strains
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Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors
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Receptors, N-Methyl-D-Aspartate / drug effects
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Receptors, N-Methyl-D-Aspartate / physiology*
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gamma-Aminobutyric Acid / pharmacology
Substances
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Organophosphorus Compounds
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Piperazines
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Quinoxalines
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Receptors, N-Methyl-D-Aspartate
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SDZ EAA 494
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Aspartic Acid
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Gallopamil
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gamma-Aminobutyric Acid
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N-Methylaspartate
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6-Cyano-7-nitroquinoxaline-2,3-dione
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2-Amino-5-phosphonovalerate
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Magnesium
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Calcium
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Glycine