Abstract
Bilateral 6-hydroxydopamine lesions of the rat locus coeruleus (a) depleted forebrain norepinephrine levels by 67%, (b) reduced the basal release of dopamine in the nucleus accumbens and caudate nucleus by 26% and 19%, respectively, and (c) reduced (+)-amphetamine-induced release in the nucleus accumbens and caudate nucleus. The locus coeruleus appears to exert a tonic excitatory influence on striatal and limbic dopamine release in vivo.
MeSH terms
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3,4-Dihydroxyphenylacetic Acid / pharmacology
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Animals
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Caudate Nucleus / metabolism*
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Chromatography, High Pressure Liquid
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Dextroamphetamine / pharmacology
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Dialysis
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Dopamine / metabolism*
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Hydroxydopamines / pharmacology
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Hydroxyindoleacetic Acid / metabolism
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Limbic System / drug effects
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Limbic System / metabolism
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Locus Coeruleus / physiology*
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Male
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Norepinephrine / metabolism
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Nucleus Accumbens / metabolism*
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Oxidopamine
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Rats
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Rats, Inbred Strains
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Sympathectomy, Chemical
Substances
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Hydroxydopamines
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3,4-Dihydroxyphenylacetic Acid
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Hydroxyindoleacetic Acid
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Oxidopamine
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Dextroamphetamine
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Dopamine
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Norepinephrine