Abstract
Until 10 years ago, conventional wisdom held that Parkinson's disease was not a genetic disorder. Since that time, there have been a plethora of genetic findings, culminating in the cloning of several genes that derive from the loci given the nomenclature PARK1-PARK12 (OMIM 168600). Recently, these research findings have begun to impact clinical practice, and this impact is likely to increase. The primary purpose of this article is to outline these genetic advances, discuss their importance for current practice in clinical and related settings, and outline briefly how they are influencing research into the causes of and possible future treatments for this prevalent disorder.
Publication types
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Research Support, N.I.H., Intramural
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Review
MeSH terms
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Aged
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Humans
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Intracellular Signaling Peptides and Proteins / genetics
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Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
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Oncogene Proteins / genetics
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Parkinson Disease / epidemiology
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Parkinson Disease / genetics*
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Parkinsonian Disorders / epidemiology
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Parkinsonian Disorders / genetics*
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Protein Deglycase DJ-1
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Protein Kinases / genetics
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Protein Serine-Threonine Kinases / genetics
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Risk
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Ubiquitin-Protein Ligases / genetics
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alpha-Synuclein / genetics
Substances
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Intracellular Signaling Peptides and Proteins
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Oncogene Proteins
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alpha-Synuclein
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Ubiquitin-Protein Ligases
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parkin protein
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Protein Kinases
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LRRK2 protein, human
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Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
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PTEN-induced putative kinase
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Protein Serine-Threonine Kinases
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PARK7 protein, human
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Protein Deglycase DJ-1