Abstract
Arc/Arg3.1 is robustly induced by plasticity-producing stimulation and specifically targeted to stimulated synaptic areas. To investigate the role of Arc/Arg3.1 in synaptic plasticity and learning and memory, we generated Arc/Arg3.1 knockout mice. These animals fail to form long-lasting memories for implicit and explicit learning tasks, despite intact short-term memory. Moreover, they exhibit a biphasic alteration of hippocampal long-term potentiation in the dentate gyrus and area CA1 with an enhanced early and absent late phase. In addition, long-term depression is significantly impaired. Together, these results demonstrate a critical role for Arc/Arg3.1 in the consolidation of enduring synaptic plasticity and memory storage.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Analysis of Variance
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Animals
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Avoidance Learning / physiology
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Behavior, Animal
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Blotting, Southern / methods
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Blotting, Western / methods
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Conditioning, Classical / physiology
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Cytoskeletal Proteins / deficiency
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Cytoskeletal Proteins / physiology*
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Dose-Response Relationship, Radiation
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Electric Stimulation / methods
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Excitatory Postsynaptic Potentials / genetics
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Excitatory Postsynaptic Potentials / physiology
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Hippocampus / cytology
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In Vitro Techniques
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Kainic Acid
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Male
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Maze Learning / physiology
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Memory / physiology*
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Mice
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Mice, Knockout
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Nerve Tissue Proteins / deficiency
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Nerve Tissue Proteins / physiology*
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Neuronal Plasticity / genetics
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Neuronal Plasticity / physiology*
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Neurons / physiology
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Patch-Clamp Techniques / methods
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Seizures / chemically induced
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Seizures / metabolism
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Spatial Behavior / physiology
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Synapses / genetics
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Synapses / physiology*
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Time Factors
Substances
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Cytoskeletal Proteins
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Nerve Tissue Proteins
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activity regulated cytoskeletal-associated protein
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Kainic Acid