Abstract
Chondroitin sulfate proteoglycans are the principal inhibitory component of glial scars, which form after damage to the adult central nervous system and act as a barrier to regenerating axons. Recent findings have furthered our understanding of the mechanisms that result in a failure of regeneration after spinal cord injury and suggest that a multipartite approach will be required to facilitate long-distance regeneration and functional recovery.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Animals
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Central Nervous System / injuries
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Central Nervous System / metabolism*
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Central Nervous System / physiopathology
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Chondroitin Sulfate Proteoglycans / metabolism*
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Cicatrix / metabolism
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Cicatrix / physiopathology
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Cicatrix / prevention & control
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Extracellular Matrix / metabolism*
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Gliosis / metabolism
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Gliosis / physiopathology
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Gliosis / prevention & control
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Growth Cones / metabolism
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Growth Cones / ultrastructure
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Growth Inhibitors / metabolism
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Humans
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Nerve Regeneration / physiology*
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Spinal Cord Injuries / metabolism*
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Spinal Cord Injuries / physiopathology
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Spinal Cord Injuries / therapy
Substances
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Chondroitin Sulfate Proteoglycans
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Growth Inhibitors