Premotor cortex modulates somatosensory cortex during voluntary movements without proprioceptive feedback

Nat Neurosci. 2007 Apr;10(4):417-9. doi: 10.1038/nn1873. Epub 2007 Mar 18.

Abstract

Movement perception relies on sensory feedback, but the involvement of efference copies remains unclear. We investigated movements without proprioceptive feedback using ischemic nerve block during fMRI in healthy humans, and found preserved activation of the primary somatosensory cortex. This activation was associated with increased interaction with premotor cortex during voluntary movements, which demonstrates that perception of movements relies in part on predictions of sensory consequences of voluntary movements that are mediated by the premotor cortex.

MeSH terms

  • Adult
  • Brain Mapping
  • Electrocardiography / methods
  • Evoked Potentials, Somatosensory
  • Feedback*
  • Female
  • Humans
  • Image Processing, Computer-Assisted / methods
  • Linear Models
  • Male
  • Motor Cortex / physiology*
  • Movement*
  • Oxygen / blood
  • Photic Stimulation / methods
  • Psychomotor Performance
  • Somatosensory Cortex / blood supply
  • Somatosensory Cortex / physiology*

Substances

  • Oxygen