Abstract
Psalmotoxin 1, a peptide extracted from the South American tarantula Psalmopoeus cambridgei, has very potent analgesic properties against thermal, mechanical, chemical, inflammatory and neuropathic pain in rodents. It exerts its action by blocking acid-sensing ion channel 1a, and this blockade results in an activation of the endogenous enkephalin pathway. The analgesic properties of the peptide are suppressed by antagonists of the mu and delta-opioid receptors and are lost in Penk1-/- mice.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acid Sensing Ion Channels
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Analgesics / therapeutic use*
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Animals
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Area Under Curve
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Behavior, Animal
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Disease Models, Animal
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Dose-Response Relationship, Drug
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Enkephalins / deficiency
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Enkephalins / physiology*
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Membrane Proteins / deficiency
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Membrane Proteins / physiology*
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Mice
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Mice, Knockout
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Morphine / administration & dosage
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Naloxone / administration & dosage
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Naltrexone / administration & dosage
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Narcotic Antagonists / administration & dosage
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Nerve Tissue Proteins / deficiency
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Nerve Tissue Proteins / physiology*
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Neurons / drug effects
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Neurons / physiology
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Pain / drug therapy*
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Pain Measurement / methods
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Peptides
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Protein Precursors / deficiency
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Reaction Time / drug effects
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Sodium Channels / deficiency
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Sodium Channels / physiology*
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Spider Venoms / therapeutic use*
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Spinal Cord / pathology
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Time Factors
Substances
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ASIC1 protein, mouse
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Acid Sensing Ion Channels
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Analgesics
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Enkephalins
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Membrane Proteins
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Narcotic Antagonists
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Nerve Tissue Proteins
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PcTX1 protein, Psalmopoeus cambridgei
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Peptides
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Protein Precursors
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Sodium Channels
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Spider Venoms
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Naloxone
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Naltrexone
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Morphine
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preproenkephalin