Abstract
Clusterin is a protein involved in multiple biological events, including neuronal cytoprotection, membrane recycling and regulation of complement-mediated membrane attack after injury. We investigated the effect of recombinant human clusterin in preclinical models of peripheral neuropathies. Daily treatment with clusterin accelerated the recovery of nerve motor evoked potential parameters after sciatic nerve injury. Prophylactic or therapeutic treatment of experimental autoimmune neuritis rats with clusterin also accelerated the rate of recovery from the disease, associated with remyelination of demyelinated nerve fibers. These data demonstrate that clusterin is capable of ameliorating clinical, neurophysiological and pathological signs in models of peripheral neuropathies.
MeSH terms
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Animals
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Clusterin / immunology
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Clusterin / pharmacology*
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Clusterin / therapeutic use
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Cytokines / drug effects
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Cytokines / immunology
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Cytokines / metabolism
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Disease Models, Animal
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Encephalomyelitis, Autoimmune, Experimental / drug therapy
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Encephalomyelitis, Autoimmune, Experimental / immunology
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Encephalomyelitis, Autoimmune, Experimental / physiopathology
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Female
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Hippocampus / immunology
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Hippocampus / metabolism
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Hippocampus / pathology
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Mice
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Mice, Inbred C57BL
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Myelin Basic Protein / drug effects
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Myelin Basic Protein / immunology
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Myelin Basic Protein / metabolism
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Myelin Sheath / drug effects
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Myelin Sheath / immunology
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Myelin Sheath / pathology
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Nerve Growth Factors / immunology
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Nerve Growth Factors / pharmacology*
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Nerve Growth Factors / therapeutic use
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Nerve Regeneration / drug effects*
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Nerve Regeneration / immunology
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Neurons / drug effects
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Neurons / immunology
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Neurons / pathology
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Organ Culture Techniques
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Peripheral Nerves / drug effects*
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Peripheral Nerves / immunology
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Peripheral Nerves / physiopathology
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Peripheral Nervous System Diseases / drug therapy*
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Peripheral Nervous System Diseases / immunology
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Peripheral Nervous System Diseases / physiopathology
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Recombinant Proteins / immunology
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Recombinant Proteins / pharmacology
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Recombinant Proteins / therapeutic use
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Sciatic Neuropathy / drug therapy
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Sciatic Neuropathy / immunology
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Sciatic Neuropathy / physiopathology
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Treatment Outcome
Substances
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CLU protein, human
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Clusterin
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Cytokines
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Myelin Basic Protein
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Nerve Growth Factors
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Recombinant Proteins