We used computer simulations to evaluate different procedures for measuring changes in the onset latency of a representative range of event-related components (the auditory and visual N1, P3, N2pc, and the frequency-related P3 difference wave). These procedures included several techniques to determine onset latencies combined with approaches using both single-participant average waveforms and jackknife-subsample average waveforms. In general, the jackknife-based approach combined with the relative criterion technique or combined with the fractional area technique (J.C. Hansen & S.A. Hillyard, 1980; S.J. Luck, 2005) provided the most accurate method and the greatest statistical power, with no inflation of Type I error rate.