Abstract
Higher-order actin-based networks (actin superstructures) are important for growth-cone motility and guidance. Principles for generating, organizing and remodelling actin superstructures have emerged from recent findings in cell-free systems, non-neuronal cells and growth cones. This Review examines how actin superstructures are initiated de novo at the leading-edge membrane and how the spontaneous organization of actin superstructures is driven by ensembles of actin-binding proteins. How the regulation of actin-binding proteins can affect growth-cone turning and axonal regeneration is also discussed.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Actin Cytoskeleton / metabolism*
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Actin Cytoskeleton / ultrastructure
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Animals
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Cell Differentiation / physiology*
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Cell Membrane / metabolism
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Cell Membrane / ultrastructure
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Cell Movement / physiology
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Central Nervous System / cytology
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Central Nervous System / embryology*
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Central Nervous System / metabolism*
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Growth Cones / metabolism*
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Growth Cones / ultrastructure
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Humans
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Microfilament Proteins / metabolism*
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Neural Pathways / cytology
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Neural Pathways / embryology
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Neural Pathways / metabolism
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Neuronal Plasticity / physiology