Abstract
The Nogo receptor (NgR), which was identified as a common receptor for three axon growth inhibitors associated with myelin, has been extensively characterized for its role in triggering growth cone collapse and arresting neurite/axon growth. Recent studies indicate that NgR is also expressed in nonneuronal cells and modulates macrophage responses during inflammation after peripheral nerve injury. In this article, we discuss the possibility that NgR might have wider effects on inflammation in a variety of neurological conditions ranging from central nervous system trauma to diseases such as multiple sclerosis or Alzheimer's disease.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Alzheimer Disease / immunology
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Alzheimer Disease / pathology
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Animals
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Enzyme Activation
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GPI-Linked Proteins
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Humans
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Inflammation / metabolism*
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Macrophages / metabolism
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Microglia / metabolism
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Multiple Sclerosis / immunology
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Multiple Sclerosis / pathology
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Myelin Proteins / genetics
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Myelin Proteins / metabolism*
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Nervous System Diseases / metabolism*
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Nervous System Diseases / pathology
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Nogo Proteins
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Nogo Receptor 1
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Receptors, Cell Surface / genetics
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Receptors, Cell Surface / metabolism*
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Spinal Cord Injuries / immunology
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Spinal Cord Injuries / pathology
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Wallerian Degeneration / metabolism
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rho GTP-Binding Proteins / metabolism
Substances
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GPI-Linked Proteins
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Myelin Proteins
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Nogo Proteins
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Nogo Receptor 1
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RTN4 protein, human
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RTN4R protein, human
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Receptors, Cell Surface
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rho GTP-Binding Proteins