Abstract
Voltage-dependent potassium, sodium and calcium ion channels may share a common mechanism of activation, in which the conserved S4 sequence acts as the primary voltage sensor. Site-directed mutagenesis of the S4 sequence of the Shaker potassium channel and electrophysiological analysis suggest that voltage-dependent activation involves the S4 sequence but is not solely due to electrostatic interactions.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Calcium Channels / chemistry
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Cloning, Molecular
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Drosophila melanogaster / genetics*
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Electric Conductivity
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Electrochemistry
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Electrophysiology
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Ion Channel Gating / physiology
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Mutagenesis, Site-Directed*
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Oocytes / metabolism
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Potassium Channels / chemistry
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Potassium Channels / genetics*
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Potassium Channels / physiology
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Protein Conformation
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Sequence Homology, Nucleic Acid
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Sodium Channels / chemistry
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Structure-Activity Relationship
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Transfection
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Xenopus
Substances
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Calcium Channels
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Potassium Channels
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Sodium Channels