Abstract
NMDA receptors are necessary for both synaptic potentiation and depression, but the precise location of these receptors has not been established. By loading MK-801 into pre- or postsynaptic neurons during paired recordings of synaptically connected layer 4 and layer 2/3 neurons in mouse barrel cortex, we found that synaptic potentiation requires postsynaptic, but not presynaptic, NMDA receptors, whereas synaptic depression requires presynaptic, but not postsynaptic, NMDA receptors.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Action Potentials / drug effects
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Action Potentials / physiology*
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Action Potentials / radiation effects
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Animals
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Animals, Newborn
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Dizocilpine Maleate / pharmacology
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Dose-Response Relationship, Radiation
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Electric Stimulation
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Excitatory Amino Acid Antagonists / pharmacology
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In Vitro Techniques
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Long-Term Potentiation / drug effects
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Long-Term Potentiation / physiology
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Long-Term Potentiation / radiation effects
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Long-Term Synaptic Depression / drug effects
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Long-Term Synaptic Depression / physiology*
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Long-Term Synaptic Depression / radiation effects
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Mice
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Mice, Inbred C57BL
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Patch-Clamp Techniques / methods
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Presynaptic Terminals / drug effects
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Presynaptic Terminals / physiology*
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Presynaptic Terminals / radiation effects
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Pyramidal Cells / drug effects
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Pyramidal Cells / physiology
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Pyramidal Cells / radiation effects
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Receptors, N-Methyl-D-Aspartate / physiology*
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Somatosensory Cortex / cytology
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Valine / analogs & derivatives
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Valine / pharmacology
Substances
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Excitatory Amino Acid Antagonists
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Receptors, N-Methyl-D-Aspartate
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Dizocilpine Maleate
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2-amino-5-phosphopentanoic acid
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Valine