Comment on "Genetically determined differences in learning from errors"

Michael Lucht; Dieter Rosskopf

doi:10.1126/science.1156079

Comment on "Genetically determined differences in learning from errors"

Science. 2008 Jul 11;321(5886):200; author reply 200. doi: 10.1126/science.1156079.

Authors

Michael Lucht¹, Dieter Rosskopf

Affiliation

¹ Hospital for Psychiatry and Psychotherapy, Haus 30, Ernst-Moritz-Arndt University, Greifswald, Stralsund 18437, Germany. lucht@uni-greifswald.de

PMID: 18621654
DOI: 10.1126/science.1156079

Abstract

Klein et al. (Reports, 7 December 2007, p. 1642) used individuals with a polymorphism adjacent to the dopamine receptor 2 gene as naturally occurring models for reduced brain dopamine receptor density in a probabilistic learning task. We raise the concern that this polymorphism resides in the gene for the kinase ANKK1, where it causes a nonconservative amino acid exchange.

Publication types

Comment

MeSH terms

Alleles
Brain / metabolism
Cloning, Molecular
Humans
Learning*
Polymorphism, Genetic*
Protein Serine-Threonine Kinases / genetics*
Protein Serine-Threonine Kinases / physiology
Proteins / genetics
Proteins / physiology
Receptors, Dopamine D2 / genetics*
Receptors, Dopamine D2 / metabolism
Signal Transduction

Substances

Proteins
Receptors, Dopamine D2
TTC12 protein, human
ANKK1 protein, human
Protein Serine-Threonine Kinases