Abstract
It is widely accepted that the process of retinal cell fate determination is under tight transcriptional control mediated by a combinatorial code of transcription factors. However, the exact repertoire of factors necessary for the genesis of each retinal cell type remains to be fully defined. Here we show that the HMG-box transcription factor, Sox9, is expressed in multipotent mouse retinal progenitor cells throughout retinogenesis. We also find that Sox9 is downregulated in differentiating neuronal populations, yet expression in Müller glial cells persists into adulthood. Furthermore, by employing a conditional knockout approach, we show that Sox9 is essential for the differentiation and/or survival of postnatal Müller glial cells.
Copyright 2008 Wiley-Liss, Inc.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Biomarkers / metabolism
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Eye Proteins / genetics
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Eye Proteins / metabolism
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High Mobility Group Proteins / genetics
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High Mobility Group Proteins / metabolism*
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Homeodomain Proteins / genetics
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Homeodomain Proteins / metabolism
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Humans
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Mice
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Mice, Inbred C57BL
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Mice, Knockout
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Multipotent Stem Cells / cytology
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Multipotent Stem Cells / metabolism*
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Mutation
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Neuroglia / cytology
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Neuroglia / physiology*
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PAX6 Transcription Factor
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Paired Box Transcription Factors / genetics
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Paired Box Transcription Factors / metabolism
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Repressor Proteins / genetics
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Repressor Proteins / metabolism
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Retina* / cytology
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Retina* / physiology
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SOX9 Transcription Factor
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Transcription Factors / genetics
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Transcription Factors / metabolism*
Substances
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Biomarkers
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Eye Proteins
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High Mobility Group Proteins
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Homeodomain Proteins
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PAX6 Transcription Factor
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PAX6 protein, human
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Paired Box Transcription Factors
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Pax6 protein, mouse
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Repressor Proteins
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SOX9 Transcription Factor
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SOX9 protein, human
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Sox9 protein, mouse
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Transcription Factors