Abstract
By the use of anti-omega-CTx antibodies in indirect immunofluorescence we demonstrated the presence of omega-CTx binding sites in the presynaptic compartment of frog nerve-muscle preparations. The images we obtained indicate that omega-CTx-sensitive channels are clustered at discrete sites corresponding in distribution to active zones.
MeSH terms
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Animals
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Anura
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Calcium Channel Blockers / pharmacology*
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Fluorescent Antibody Technique
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In Vitro Techniques
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Neuromuscular Junction / chemistry
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Neuromuscular Junction / drug effects*
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Peptides, Cyclic / pharmacology*
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omega-Conotoxins*
Substances
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Calcium Channel Blockers
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Peptides, Cyclic
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omega-Conotoxins
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Conus magus toxin