Abstract
GTPases are conserved molecular switches, built according to a common structural design. Rapidly accruing knowledge of individual GTPases--crystal structures, biochemical properties, or results of molecular genetic experiments--support and generate hypotheses relating structure to function in other members of the diverse family of GTPases.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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GTP Phosphohydrolase-Linked Elongation Factors / physiology*
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GTP Phosphohydrolase-Linked Elongation Factors / ultrastructure
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GTP-Binding Proteins / metabolism
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Guanosine Diphosphate / metabolism
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Guanosine Triphosphate / metabolism
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Humans
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Molecular Sequence Data
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Peptide Elongation Factors / metabolism
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Peptide Initiation Factors / metabolism
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Protein Conformation
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Protein Processing, Post-Translational
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Proto-Oncogene Proteins p21(ras) / metabolism
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Signal Transduction
Substances
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Peptide Elongation Factors
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Peptide Initiation Factors
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Guanosine Diphosphate
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Guanosine Triphosphate
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GTP Phosphohydrolase-Linked Elongation Factors
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GTP-Binding Proteins
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HRAS protein, human
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Proto-Oncogene Proteins p21(ras)